In the image of a singer who has already sold millions of disks, a best of has been created with numerous hits so that fans can have a single album, Guitar Hero Greatest Hits is a compilation from almost all of the Guitar Hero releases up to today. This new release offers the "best" tracks, both in terms of game play and the popularity of the groups, coming from Guitar Hero I, Guitar Hero II, Guitar Hero III, Rocks the 80's and Guitar Hero Aerosmith. This is a selection which will certainly get people talking: selecting only forty-eight tracks from all of the previous play lists means that some sacrifices will have to be made. Some players will be disappointed that their favourite songs missed out, while others will be happy to see much loved songs included.

While the choices on the play lists show themselves to be more or less relevant to some players, all are bought together by a single: this Guitar Hero Greatest Hits shows itself to be particularly bare in terms of content. Forty-eight tracks seems to be a little light once you are used to the series. The price of the game on the other hand hasn’t come down a bit, which means that it is easier to skip over the acquisition of the game. The main interest of the game is to offer new tracks, saving your ears from the filler on the original games. Guitar Hero Greatest Hits surely has to pay the price for these official songs, which means it really is a "very best of"...

The complete Track list in Guitar Hero Greatest Hits:
Guitar Hero
- Blue Öyster Cult - “Godzilla”
- Boston - “More Than A Feeling”
- Deep Purple - “Smoke On The Water”
- Franz Ferdinand - “Take Me Out”
- Helmet - “Unsung (Live)”
- Incubus - “Stellar”
- Joan Jett & The Blackhearts - “I Love Rock N' Roll”
- Ozzy Osbourne - “Bark At The Moon”
- Pantera - “Cowboys From Hell (Live)”
- Queen - “Killer Queen”
- Queens Of The Stone Age - “No One Knows”
- The Donnas - “Take It Off”
- The Exies - “Hey You”
- White Zombie - “Thunder Kiss '65”
Guitar Hero II
- Alice In Chains - “Them Bones”
- Avenged Sevenfold - “Beast And The Harlot”
- Danzig - “Mother”
- Foo Fighters - “Monkey Wrench”
- Iron Maiden - “The Trooper”
- Jane's Addiction - “Stop!”
- Kansas - “Carry On Wayward Son”
- Lamb Of God - “Laid To Rest”
- Lynyrd Skynyrd - “Free Bird”
- Mötley Crüe- “Shout At The Devil”
- Nirvana - “Heart-Shaped Box”
- Rage Against The Machine - “Killing In The Name”
- Reverend Horton Heat - “Psychobilly Freakout”
- Rush - “YYZ”
- Stone Temple Pilots - “Trippin' On A Hole In A Paper Heart”
- The Police - “Message In A Bottle”
- The Sword - “Freya”
- Warrant - “Cherry Pie”
- Wolfmother - “Woman”
Guitar Hero Encore: Rocks the 80s
- Anthrax - “Caught In A Mosh”
- Extreme - “Play With Me”
- Judas Priest - “Electric Eye”
- Poison - “Nothin' But A Good Time”
- Ratt - “Round and Round”
- Twisted Sister - “I Wanna Rock”
- Guitar Hero III: Legends of Rock
- AFI - “Miss Murder”
- DragonForce - “Through The Fire And Flames”
- Heart - “Barracuda”
- Kiss - “Rock And Roll All Nite”
- Living Colour - “Cult Of Personality”
- Priestess - “Lay Down”
- Slayer - “Raining Blood”
Guitar Hero: Aerosmith
- Aerosmith - “Back In The Saddle”